Reactome | Hypusine synthesis from eIF5A-lysine

Schema > Pathway > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10826459
displayName	Hypusine synthesis from eIF5A-lysine
eventOf	[Pathway:R-GGA-163841] Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:25397] peptidyl-hypusine biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-204662] DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A - Gallus gallus
inferredFrom	[Pathway:R-HSA-204626] Hypusine synthesis from eIF5A-lysine - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Hypusine synthesis from eIF5A-lysine Hypusinylation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-204626
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-GGA-163841] Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
(inferredTo)	[Pathway:R-HSA-204626] Hypusine synthesis from eIF5A-lysine

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