Reactome | Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8

Schema > BlackBoxEvent > Entries

Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 Show undefined attributes

catalystActivity	[CatalystActivity:10748166] ubiquitin protein ligase activity of SMURF [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10748168
displayName	Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8
eventOf	[Pathway:R-GGA-201451] Signaling by BMP - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:23767] negative regulation of BMP signaling pathway
inferredFrom	[BlackBoxEvent:R-HSA-201445] Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 - Homo sapiens
input	[DefinedSet:R-GGA-201424] SMAD1/5/8 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-201445
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-201451] Signaling by BMP
(inferredTo)	[BlackBoxEvent:R-HSA-201445] Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8

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