Reactome | DLL4 binds NOTCH2

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10775926
displayName	DLL4 binds NOTCH2
eventOf	[Pathway:R-GGA-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1980051] DLL4 binds NOTCH2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-158437] DLL4 [plasma membrane] [Complex:R-GGA-157005] NOTCH2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	DLL4 binds NOTCH2
output	[Complex:R-GGA-1980053] DLL4:NOTCH2 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-GGA-1912382] Mature NOTCH heterodimer traffics to the plasma membrane - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-1980051
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-GGA-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus
(inferredTo)	[Reaction:R-HSA-1980051] DLL4 binds NOTCH2