Reactome | PANK2 phosphorylates PanK

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PANK2 phosphorylates PanK Show undefined attributes

catalystActivity	[CatalystActivity:10746722] pantothenate kinase activity of PANK2(141-570) [mitochondrial intermembrane space]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10746724
displayName	PANK2 phosphorylates PanK
eventOf	[Pathway:R-GGA-196783] Coenzyme A biosynthesis - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-196753] 2xPPCS ligates PPanK with Cys - Gallus gallus
inferredFrom	[Reaction:R-HSA-196857] PANK2 phosphorylates PanK - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-196820] PanK [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PANK2 phosphorylates PanK (R)-pantothenate + ATP => (R)-4'-phosphopantothenate + ADP + H(+)
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-196786] PPanK [cytosol]
precedingEvent	[Reaction:R-GGA-199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol - Gallus gallus
regulatedBy	[NegativeRegulation:9837290] Negative regulation by 'CoA-SH [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-196857
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-196783] Coenzyme A biosynthesis
(precedingEvent)	[Reaction:R-GGA-196753] 2xPPCS ligates PPanK with Cys
(inferredTo)	[Reaction:R-HSA-196857] PANK2 phosphorylates PanK

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