Reactome | CYP17A1 cleaves 17aHPROG to ANDST

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CYP17A1 cleaves 17aHPROG to ANDST Show undefined attributes

catalystActivity	[CatalystActivity:10746061] steroid 17-alpha-monooxygenase activity of CYP17A1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10746069
displayName	CYP17A1 cleaves 17aHPROG to ANDST
eventOf	[Pathway:R-GGA-193048] Androgen biosynthesis - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-193060] CYP19A1 hydroxylates ANDST to E1 - Gallus gallus [Reaction:R-GGA-193064] HSD17B3-like proteins reducde ANDST to TEST - Gallus gallus [Reaction:R-GGA-9705925] Androgens binds AR (in the HSP90 chaperone complex) - Gallus gallus
inferredFrom	[Reaction:R-HSA-193099] CYP17A1 cleaves 17aHPROG to ANDST - Homo sapiens
input	[SimpleEntity:R-ALL-193092] 17aHPROG [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP17A1 cleaves 17aHPROG to ANDST Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione 17alpha-hydroxyprogesterone + NADPH + H+ + O2 => 4-Androstene-3, 17-dione + NADP+ + H2O + acetaldehyde
output	[SimpleEntity:R-ALL-193079] ANDST [cytosol] [SimpleEntity:R-ALL-29510] CH3CHO [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-GGA-193072] CYP17A1 17-hydroxylates P4 to 17aHPROG - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-193099
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-GGA-193060] CYP19A1 hydroxylates ANDST to E1 [Reaction:R-GGA-9705925] Androgens binds AR (in the HSP90 chaperone complex) [Reaction:R-GGA-193064] HSD17B3-like proteins reducde ANDST to TEST
(hasEvent)	[Pathway:R-GGA-193048] Androgen biosynthesis
(inferredTo)	[Reaction:R-HSA-193099] CYP17A1 cleaves 17aHPROG to ANDST

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