Reactome | Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol

Schema > Reaction > Entries

Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol Show undefined attributes

catalystActivity	[CatalystActivity:10746029] cholesterol monooxygenase (side-chain-cleaving) activity of CYP11A1:FDXR:FDX1,FDX1L (red.) [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10746056
displayName	Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol
eventOf	[Pathway:R-GGA-196108] Pregnenolone biosynthesis - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-193101] CYP11A1 cleaves 20a,22b-DHCHOL - Gallus gallus
inferredFrom	[Reaction:R-HSA-193065] Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol - Homo sapiens
input	[SimpleEntity:R-ALL-193019] 22b-HCHOL [mitochondrial inner membrane] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix] [SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol 22beta-hydroxycholesterol + NADPH + H+ + O2 => 20alpha,22beta-hydroxycholesterol + NADP+ + H2O
output	[SimpleEntity:R-ALL-193086] 20a,22b-DHCHOL [mitochondrial inner membrane] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
precedingEvent	[Reaction:R-GGA-193054] Oxidation of cholesterol to 22beta-hydroxycholesterol - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-193065
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-196108] Pregnenolone biosynthesis
(precedingEvent)	[Reaction:R-GGA-193101] CYP11A1 cleaves 20a,22b-DHCHOL
(inferredTo)	[Reaction:R-HSA-193065] Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol

Cite Us!