Reactome | CYP7B1 7-hydroxylates 25OH-CHOL

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CYP7B1 7-hydroxylates 25OH-CHOL Show undefined attributes

catalystActivity	[CatalystActivity:10745846] oxysterol 7-alpha-hydroxylase activity of Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10745906
displayName	CYP7B1 7-hydroxylates 25OH-CHOL
eventOf	[Pathway:R-GGA-211976] Endogenous sterols - Gallus gallus [Pathway:R-GGA-192105] Synthesis of bile acids and bile salts - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-192065] CYP7B1 7-hydroxylates 25OH-CHOL - Homo sapiens
input	[SimpleEntity:R-ALL-192148] 25OH-CHOL [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP7B1 7-hydroxylates 25OH-CHOL 25-hydroxycholesterol + O2 + reduced (NADPH--hemoprotein reductase) => 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
output	[SimpleEntity:R-ALL-192184] CHOL3b,7a,25TRIOL [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-GGA-5340195] NR1H4 binds DCA, CDCA, LCHA - Gallus gallus
regulatedBy	[NegativeRegulation:10745869] Negative regulation by 'NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-192065
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-192105] Synthesis of bile acids and bile salts [Pathway:R-GGA-211976] Endogenous sterols
(inferredTo)	[Reaction:R-HSA-192065] CYP7B1 7-hydroxylates 25OH-CHOL

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