Reactome | Phosphorylation of Cx43 by c-src

Schema > Reaction > Entries

Phosphorylation of Cx43 by c-src Show undefined attributes

catalystActivity	[CatalystActivity:10745695] protein tyrosine kinase activity of Cx43:ZO-1:c-src gap junction [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10745697
displayName	Phosphorylation of Cx43 by c-src
eventOf	[Pathway:R-GGA-191650] Regulation of gap junction activity - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-191656] Closure of gap junction - Gallus gallus
inferredFrom	[Reaction:R-HSA-191636] Phosphorylation of Cx43 by c-src - Homo sapiens
input	12 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-GGA-191653] Cx43:ZO-1:c-src gap junction [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of Cx43 by c-src
output	12 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-GGA-191645] phospho-Y265 Cx43:ZO-1 gap junction [plasma membrane]
precedingEvent	[Reaction:R-GGA-191654] c-src associates with Cx43 in gap junctions - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-191636
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-191650] Regulation of gap junction activity
(precedingEvent)	[Reaction:R-GGA-191656] Closure of gap junction
(inferredTo)	[Reaction:R-HSA-191636] Phosphorylation of Cx43 by c-src

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