Reactome | PPO oxidises PPGEN9 to PRIN9

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PPO oxidises PPGEN9 to PRIN9 Show undefined attributes

catalystActivity	[CatalystActivity:10745182] oxygen-dependent protoporphyrinogen oxidase activity of 2xPPOX:FAD [mitochondrial intermembrane space]
category	transition
compartment	[Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10745184
displayName	PPO oxidises PPGEN9 to PRIN9
eventOf	[Pathway:R-GGA-189451] Heme biosynthesis - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-189423] PPO oxidises PPGEN9 to PRIN9 - Homo sapiens
input	3 × [SimpleEntity:R-ALL-189461] O2 [mitochondrial intermembrane space] [SimpleEntity:R-ALL-189478] PPGEN9 [mitochondrial intermembrane space]
isInDisease	false
isInferred	true
maxDepth	1
name	PPO oxidises PPGEN9 to PRIN9 3 O2 + protoporphyrinogen IX => 3 H2O2 + protoporphyrin IX Oxidation of protoporphyrinogen IX to protoporphyrin IX
output	3 × [SimpleEntity:R-ALL-189481] H2O2 [mitochondrial intermembrane space] [SimpleEntity:R-ALL-189463] PRIN9 [mitochondrial intermembrane space]
precedingEvent	[Reaction:R-GGA-189421] CPO transforms COPRO3 to PPGEN9 - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-189423
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-189451] Heme biosynthesis
(inferredTo)	[Reaction:R-HSA-189423] PPO oxidises PPGEN9 to PRIN9

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