Reactome | TRIF:activated TLR3/TLR4 complex recruits RIP1

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TRIF:activated TLR3/TLR4 complex recruits RIP1 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10742622
displayName	TRIF:activated TLR3/TLR4 complex recruits RIP1
eventOf	[Pathway:R-GGA-937041] IKK complex recruitment mediated by RIP1 - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Gallus gallus [Reaction:R-GGA-2562541] TLR4-induced ripoptosome assembly - Gallus gallus
inferredFrom	[Reaction:R-HSA-168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-GGA-168651] RIPK1 [cytosol] [Complex:R-GGA-166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TRIF:activated TLR3/TLR4 complex recruits RIP1
output	[Complex:R-GGA-168912] RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
precedingEvent	[Reaction:R-GGA-166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - Gallus gallus
regulatedBy	[NegativeRegulation:10742623] Negative regulation by 'SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-168921
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-937041] IKK complex recruitment mediated by RIP1
(precedingEvent)	[Reaction:R-GGA-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex [Reaction:R-GGA-2562541] TLR4-induced ripoptosome assembly
(inferredTo)	[Reaction:R-HSA-168921] TRIF:activated TLR3/TLR4 complex recruits RIP1