Reactome | Transfer of LPS onto TLR4

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Transfer of LPS onto TLR4 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10742196
displayName	Transfer of LPS onto TLR4
eventOf	[Pathway:R-GGA-166016] Toll Like Receptor 4 (TLR4) Cascade - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-2201293] Endocytosis of TLR4:LY96:LPS:CD14 - Gallus gallus
inferredFrom	[Reaction:R-HSA-166041] Transfer of LPS onto TLR4 - Homo sapiens
input	[DefinedSet:R-GGA-166043] LPS:CD14 [extracellular region] 2 × [Complex:R-GGA-166050] TLR4:LY96 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Transfer of LPS onto TLR4
output	[Complex:R-GGA-166850] TLR4:LY96:LPS:CD14 [plasma membrane]
precedingEvent	[Reaction:R-GGA-169719] Secreted CD14 binds LPS - Gallus gallus [Reaction:R-GGA-166038] GPI-bound CD14 binds LPS - Gallus gallus
regulatedBy	[NegativeRegulation:10742197] Negative regulation by 'RP105:MD1 [plasma membrane]' [NegativeRegulation:10742198] Negative regulation by 'SFTPA oligomer, SFTPD oligomer [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-166041
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-166016] Toll Like Receptor 4 (TLR4) Cascade
(precedingEvent)	[Reaction:R-GGA-2201293] Endocytosis of TLR4:LY96:LPS:CD14
(inferredTo)	[Reaction:R-HSA-166041] Transfer of LPS onto TLR4