Reactome | Activation of proMMP9 by proteases

Schema > Reaction > Entries

Activation of proMMP9 by proteases Show undefined attributes

catalystActivity	[CatalystActivity:10773223] serine-type endopeptidase activity of proMMP9 activating proteases [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10773225
displayName	Activation of proMMP9 by proteases
eventOf	[Pathway:R-GGA-1592389] Activation of Matrix Metalloproteinases - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1604722] Activation of proMMP9 by proteases - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-1604376] MMP9(20-707) [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Activation of proMMP9 by proteases
output	[EntityWithAccessionedSequence:R-GGA-668812] MMP9(107-707) [extracellular region] [EntityWithAccessionedSequence:R-GGA-1604713] MMP9(20-106) [extracellular region]
regulatedBy	[NegativeRegulation:10772899] Negative regulation by 'COL18A1(1572-11754) [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-1604722
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-1592389] Activation of Matrix Metalloproteinases
(inferredTo)	[Reaction:R-HSA-1604722] Activation of proMMP9 by proteases

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