Reactome | Initial activation of proMMP13 by plasmin and trypsin

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Initial activation of proMMP13 by plasmin and trypsin Show undefined attributes

catalystActivity	[CatalystActivity:10773186] serine-type endopeptidase activity of Trypsin, plasmin [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10773188
displayName	Initial activation of proMMP13 by plasmin and trypsin
eventOf	[Pathway:R-GGA-1592389] Activation of Matrix Metalloproteinases - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-1604732] Autocatalytic activation of proMMP13 - Gallus gallus
inferredFrom	[Reaction:R-HSA-1602488] Initial activation of proMMP13 by plasmin and trypsin - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-1604702] MMP13(20-471) [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Initial activation of proMMP13 by plasmin and trypsin
output	[EntityWithAccessionedSequence:R-GGA-1604719] MMP13(20-57) [extracellular region] [EntityWithAccessionedSequence:R-GGA-1604698] MMP13(58-471) [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-1602488
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-1592389] Activation of Matrix Metalloproteinases
(precedingEvent)	[Reaction:R-GGA-1604732] Autocatalytic activation of proMMP13
(inferredTo)	[Reaction:R-HSA-1602488] Initial activation of proMMP13 by plasmin and trypsin

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