Reactome | DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex

Schema > Reaction > Entries

DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10772667
displayName	DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex
eventOf	[Pathway:R-GGA-4641258] Degradation of DVL - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1 - Gallus gallus
inferredFrom	[Reaction:R-HSA-1504213] DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex - Homo sapiens
input	[Complex:R-GGA-1504195] CUL3:KLHL12:RBX1 [cytosol] [CandidateSet:R-GGA-1504201] DVL [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex
output	[Complex:R-GGA-1504210] DVL:CUL3:KLHL12:RBX1 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-1504213
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-4641258] Degradation of DVL
(precedingEvent)	[Reaction:R-GGA-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1
(inferredTo)	[Reaction:R-HSA-1504213] DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex

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