Reactome | GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3

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GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10770880
displayName	GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3
eventOf	[Pathway:R-GGA-1306955] GRB7 events in ERBB2 signaling - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1306953] GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-204819] GRB7 [cytosol] [CandidateSet:R-GGA-1963572] Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3
output	[Complex:R-GGA-1306951] NRG1/2:p-10Y-ERBB3:p-ERBB2:GRB7 [plasma membrane]
precedingEvent	[Reaction:R-GGA-1963582] Trans-autophosphorylation of ERBB2 heterodimers - Gallus gallus [Reaction:R-GGA-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-1306953
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-1306955] GRB7 events in ERBB2 signaling
(inferredTo)	[Reaction:R-HSA-1306953] GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3

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