Reactome | Nuclear VBC complex ubiquitinylates HIF-alpha

Schema > Reaction > Entries

Nuclear VBC complex ubiquitinylates HIF-alpha Show undefined attributes

catalystActivity	[CatalystActivity:10769345] ubiquitin-protein transferase activity of hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10769347
displayName	Nuclear VBC complex ubiquitinylates HIF-alpha
eventOf	[Pathway:R-GGA-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-GGA-1234175] ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol - Gallus gallus
inferredFrom	[Reaction:R-HSA-1234172] Nuclear VBC complex ubiquitinylates HIF-alpha - Homo sapiens
input	[Complex:R-GGA-1234101] hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] [Complex:R-GGA-1234123] UBE2D1,2,3:Ubiquitin [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Nuclear VBC complex ubiquitinylates HIF-alpha
output	[Complex:R-GGA-1234103] ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] [DefinedSet:R-GGA-1234118] UBE2D1,2,3 [nucleoplasm]
precedingEvent	[Reaction:R-GGA-1234169] Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-1234172
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
(precedingEvent)	[BlackBoxEvent:R-GGA-1234175] ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol
(inferredTo)	[Reaction:R-HSA-1234172] Nuclear VBC complex ubiquitinylates HIF-alpha