Reactome | Activation of conventional Protein Kinase C

Schema > Reaction > Entries

Activation of conventional Protein Kinase C Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10739336
displayName	Activation of conventional Protein Kinase C
eventOf	[Pathway:R-GGA-76005] Response to elevated platelet cytosolic Ca2+ - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-114683] Phosphorylation of Platelet Sec-1 - Gallus gallus
inferredFrom	[Reaction:R-HSA-114553] Activation of conventional Protein Kinase C - Homo sapiens
input	[SimpleEntity:R-ALL-74016] Ca2+ [cytosol] [SimpleEntity:R-ALL-114519] DAG [plasma membrane] [EntityWithAccessionedSequence:R-GGA-58198] PRKCB [cytosol] [SimpleEntity:R-ALL-33625] PS [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activation of conventional Protein Kinase C
output	[Complex:R-GGA-139829] Activated PKC beta [plasma membrane]
precedingEvent	[Reaction:R-GGA-114688] PLC-beta hydrolyses PIP2 to DAG and IP3 - Gallus gallus [Reaction:R-GGA-398193] PLC beta-mediated PIP2 hydrolysis - Gallus gallus [Reaction:R-GGA-114689] PLC gamma 2-mediated PIP2 hydrolysis - Gallus gallus [Reaction:R-GGA-139855] P2X1-mediated entry of Ca++ from plasma - Gallus gallus [Reaction:R-GGA-426223] Cation influx mediated by TRPC3/6/7 - Gallus gallus [Reaction:R-GGA-139854] IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol - Gallus gallus
regulatedBy	[PositiveRegulation:R-HSA-1489502] Positive regulation by 'DAG [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-114553
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-76005] Response to elevated platelet cytosolic Ca2+
(precedingEvent)	[Reaction:R-GGA-114683] Phosphorylation of Platelet Sec-1
(inferredTo)	[Reaction:R-HSA-114553] Activation of conventional Protein Kinase C