Reactome | RAC1,RAC2,RHOG activate PI3K

Schema > Reaction > Entries

RAC1,RAC2,RHOG activate PI3K Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10739262
displayName	RAC1,RAC2,RHOG activate PI3K
eventOf	[Pathway:R-GGA-1257604] PIP3 activates AKT signaling - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Gallus gallus [Reaction:R-GGA-2316434] PI3K phosphorylates PIP2 to PIP3 - Gallus gallus
inferredFrom	[Reaction:R-HSA-114542] RAC1,RAC2,RHOG activate PI3K - Homo sapiens
input	[Complex:R-GGA-198379] PI3K alpha [cytosol] [DefinedSet:R-GGA-9615275] RAC1:GTP,RAC2:GTP,RHOG:GTP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	RAC1,RAC2,RHOG activate PI3K
output	[Complex:R-GGA-114540] RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-114542
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-1257604] PIP3 activates AKT signaling
(precedingEvent)	[Reaction:R-GGA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 [Reaction:R-GGA-2316434] PI3K phosphorylates PIP2 to PIP3
(inferredTo)	[Reaction:R-HSA-114542] RAC1,RAC2,RHOG activate PI3K