Reactome | Inhibition of replication initiation of damaged DNA by RB1/E2F1

Schema > Pathway > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10825639
displayName	Inhibition of replication initiation of damaged DNA by RB1/E2F1
eventOf	[Pathway:R-GGA-113510] E2F mediated regulation of DNA replication - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-113504] Detection of damage during initiation of DNA synthesis in S-phase - Gallus gallus
inferredFrom	[Pathway:R-HSA-113501] Inhibition of replication initiation of damaged DNA by RB1/E2F1 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Inhibition of replication initiation of damaged DNA by RB1/E2F1
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-113501
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-GGA-113510] E2F mediated regulation of DNA replication
(inferredTo)	[Pathway:R-HSA-113501] Inhibition of replication initiation of damaged DNA by RB1/E2F1

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