Reactome | glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)

Schema > Reaction > Entries

glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) Show undefined attributes

catalystActivity	[CatalystActivity:10738537] glutathione disulfide oxidoreductase activity of 2xHC-GLRX [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10738539
displayName	glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)
eventOf	[Pathway:R-GGA-499943] Interconversion of nucleotide di- and triphosphates - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Gallus gallus
inferredFrom	[Reaction:R-HSA-111746] glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-111740] GLRX [cytosol] 2 × [SimpleEntity:R-ALL-29450] GSH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (protein)-disulfide + 2 glutathione => (protein)-dithiol + glutathione disulfide
output	[EntityWithAccessionedSequence:R-GGA-55729] GLRX [cytosol] [SimpleEntity:R-ALL-111745] GSSG [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-111746
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-499943] Interconversion of nucleotide di- and triphosphates
(precedingEvent)	[Reaction:R-GGA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
(inferredTo)	[Reaction:R-HSA-111746] glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)

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