Reactome | Cleavage of thymine by MBD4 glycosylase

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:10738307] DNA N-glycosylase activity of MBD4:CpG(T:G)-dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10738309
displayName	Cleavage of thymine by MBD4 glycosylase
eventOf	[Pathway:R-GGA-110329] Cleavage of the damaged pyrimidine - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-110232] Cleavage of thymine by MBD4 glycosylase - Homo sapiens
input	[Complex:R-GGA-110170] MBD4:CpG(T:G)-dsDNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Cleavage of thymine by MBD4 glycosylase
output	[Complex:R-GGA-110194] MBD4:CpG(AP)-dsDNA [nucleoplasm] [SimpleEntity:R-ALL-29692] Thy [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-110232
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-GGA-110329] Cleavage of the damaged pyrimidine
(inferredTo)	[Reaction:R-HSA-110232] Cleavage of thymine by MBD4 glycosylase

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