Reactome | IL6:IL6R-2 binds IL6ST-2

Schema > Reaction > Entries

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10768523
displayName	IL6:IL6R-2 binds IL6ST-2
eventOf	[Pathway:R-GGA-1059683] Interleukin-6 signaling - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1067676] IL6:IL6R-2 binds IL6ST-2 - Homo sapiens
input	[Complex:R-GGA-1067687] IL6:IL6R-2 [extracellular region] [EntityWithAccessionedSequence:R-GGA-1067653] IL6ST [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	IL6:IL6R-2 binds IL6ST-2 IL6:sIL6R binds sgp130
output	[Complex:R-GGA-1067674] IL6:IL6R-2:IL6ST-2 [extracellular region]
precedingEvent	[Reaction:R-GGA-1067640] IL6 binds IL6R-2 - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-1067676
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-GGA-1059683] Interleukin-6 signaling
(inferredTo)	[Reaction:R-HSA-1067676] IL6:IL6R-2 binds IL6ST-2

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