Reactome | DHTKD1 dimer decarboxylates 2-OA

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DHTKD1 dimer decarboxylates 2-OA Show undefined attributes

catalystActivity	[CatalystActivity:10644850] oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor of OADH complex [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10644852
displayName	DHTKD1 dimer decarboxylates 2-OA
eventOf	[Pathway:R-DRE-9858328] OADH complex synthesizes glutaryl-CoA from 2-OA - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-9858590] DLST transfers glutaryl to CoA - Danio rerio
inferredFrom	[Reaction:R-HSA-9858321] DHTKD1 dimer decarboxylates 2-OA - Homo sapiens
input	[SimpleEntity:R-ALL-70951] 2-OA [mitochondrial matrix] [EntityWithAccessionedSequence:R-DRE-69993] dlst [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	DHTKD1 dimer decarboxylates 2-OA 2-oxoadipate + H(+) + N(6)-((R)-lipoyl)-L-lysyl-(dihydrolipoyllysine-residue succinyltransferase) => CO2 + N(6)-((R)-S(8)-glutaryldihydrolipoyl)-L-lysyl-(dihydrolipoyllysine-residue succinyltransferase)
output	[SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [EntityWithAccessionedSequence:R-DRE-9858581] dlst [mitochondrial matrix]
precedingEvent	[Reaction:R-DRE-372480] 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] - Danio rerio [Reaction:R-DRE-9858589] DLD dimer dehydrogenates dihydrolipoyl - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-9858321
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-9858328] OADH complex synthesizes glutaryl-CoA from 2-OA
(precedingEvent)	[Reaction:R-DRE-9858590] DLST transfers glutaryl to CoA
(inferredTo)	[Reaction:R-HSA-9858321] DHTKD1 dimer decarboxylates 2-OA

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