Reactome | JAK2 phosphorylation of GHR

Schema > Reaction > Entries

JAK2 phosphorylation of GHR Show undefined attributes

catalystActivity	[CatalystActivity:10591127] protein tyrosine kinase activity of Growth Hormone: Activated Growth Hormone Receptor- p(Y1007)-JAK2 dimer [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10591129
displayName	JAK2 phosphorylation of GHR
eventOf	[Pathway:R-DRE-982772] Growth hormone receptor signaling - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-982807] JAK2 phosphorylation of GHR - Homo sapiens
input	10 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-DRE-1168856] Growth Hormone: Activated Growth Hormone Receptor- p(Y1007)-JAK2 dimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	JAK2 phosphorylation of GHR
output	10 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-DRE-1168898] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane]
precedingEvent	[BlackBoxEvent:R-DRE-982810] JAK2 phosphorylation - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-982807
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-982772] Growth hormone receptor signaling
(inferredTo)	[Reaction:R-HSA-982807] JAK2 phosphorylation of GHR