Reactome | CDK4 inhibitors bind CDK4

Schema > Reaction > Entries

category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10641599
displayName	CDK4 inhibitors bind CDK4
eventOf	[Pathway:R-DRE-9754119] Drug-mediated inhibition of CDK4/CDK6 activity - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9754130] CDK4 inhibitors bind CDK4 - Homo sapiens
input	[DefinedSet:R-ALL-9754127] CDK4 inhibitors [nucleoplasm] [DefinedSet:R-DRE-9756821] p-T172-CDK4:CCND [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	CDK4 inhibitors bind CDK4
output	[DefinedSet:R-DRE-9754133] p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-9754130
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-9754119] Drug-mediated inhibition of CDK4/CDK6 activity
(inferredTo)	[Reaction:R-HSA-9754130] CDK4 inhibitors bind CDK4

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