Reactome | NAT1,2 acetylate APAP-Cys to APAP-Mer

Schema > Reaction > Entries

NAT1,2 acetylate APAP-Cys to APAP-Mer Show undefined attributes

catalystActivity	[CatalystActivity:10641593] arylamine N-acetyltransferase activity of NAT1,2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10641595
displayName	NAT1,2 acetylate APAP-Cys to APAP-Mer
eventOf	[Pathway:R-DRE-9753281] Paracetamol ADME - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-9753284] ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region - Danio rerio
inferredFrom	[Reaction:R-HSA-9753676] NAT1,2 acetylate APAP-Cys to APAP-Mer - Homo sapiens
input	[SimpleEntity:R-ALL-76183] Ac-CoA [cytosol] [SimpleEntity:R-ALL-9753653] APAP-Cys [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NAT1,2 acetylate APAP-Cys to APAP-Mer
output	[SimpleEntity:R-ALL-9753642] APAP-Mer [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
precedingEvent	[Reaction:R-DRE-9753632] CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-9753676
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-9753281] Paracetamol ADME
(precedingEvent)	[Reaction:R-DRE-9753284] ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region
(inferredTo)	[Reaction:R-HSA-9753676] NAT1,2 acetylate APAP-Cys to APAP-Mer

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