Reactome | LRRC14 binds IKBKB and CHUK

Schema > Reaction > Entries

LRRC14 binds IKBKB and CHUK Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10641526
displayName	LRRC14 binds IKBKB and CHUK
eventOf	[Pathway:R-DRE-9758274] Regulation of NF-kappa B signaling - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:162165] negative regulation of canonical NF-kappaB signal transduction
inferredFrom	[Reaction:R-HSA-9749505] LRRC14 binds IKBKB and CHUK - Homo sapiens
input	[EntityWithAccessionedSequence:R-DRE-168104] CHUK [cytosol] [EntityWithAccessionedSequence:R-DRE-168114] ikbkb [cytosol] [EntityWithAccessionedSequence:R-DRE-9749455] si:ch73-174h16.4 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	LRRC14 binds IKBKB and CHUK LRRC14 binds IKBKB and IKBKA
output	[Complex:R-DRE-9749467] CHUK:IKBKB:LRRC14 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-9749505
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-9758274] Regulation of NF-kappa B signaling
(inferredTo)	[Reaction:R-HSA-9749505] LRRC14 binds IKBKB and CHUK

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