Reactome | NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA

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NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA Show undefined attributes

catalystActivity	[CatalystActivity:10639232] DNA N-glycosylase activity of NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10639234
displayName	NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA
eventOf	[Pathway:R-DRE-110331] Cleavage of the damaged purine - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9629216] NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA - Homo sapiens
input	[Complex:R-DRE-9629206] NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA
output	[SimpleEntity:R-ALL-9629218] Gh [nucleoplasm] [Complex:R-DRE-9629210] NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm]
precedingEvent	[Reaction:R-DRE-9629195] NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-9629216
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-110331] Cleavage of the damaged purine
(inferredTo)	[Reaction:R-HSA-9629216] NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA

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