Reactome | EGF-like ligands:p-6Y EGFR dimer [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-DRE-182928] EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] - Danio rerio
consumedByEvent	[Reaction:R-DRE-183067] Localization of CBL:GRB2 to the membrane - Danio rerio [Reaction:R-DRE-183055] Binding of CBL to EGFR - Danio rerio [Reaction:R-DRE-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Danio rerio [Reaction:R-DRE-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10572315
displayName	EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
hasComponent	2 × [DefinedSet:R-DRE-9624194] EGF-like ligands [extracellular region] 2 × [EntityWithAccessionedSequence:R-DRE-179803] phospho-p-6Y-EGFR [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] - Homo sapiens
maxDepth	3
name	EGF-like ligands:p-6Y EGFR dimer
producedByEvent	[Reaction:R-DRE-212713] Active PLC-gamma1 dissociates from EGFR - Danio rerio [Reaction:R-DRE-177934] EGFR autophosphorylation - Danio rerio [Reaction:R-DRE-177937] Phosphorylation of EGFR by SRC kinase - Danio rerio
schemaClass	Complex
species	[Species:68323] Danio rerio
stId	R-DRE-9624425
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-DRE-183067] Localization of CBL:GRB2 to the membrane [Reaction:R-DRE-183055] Binding of CBL to EGFR [Reaction:R-DRE-177943] GRB2:SOS1 complex binds to EGF:EGFR complex [Reaction:R-DRE-212706] Phospholipase C-gamma1 binds to the activated EGF receptor
(hasComponent)	[Complex:R-DRE-182928] EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] [Complex:R-DRE-182960] EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] [Complex:R-DRE-179820] EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] [Complex:R-DRE-180337] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] [Complex:R-DRE-212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] [Complex:R-DRE-212703] EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] [Complex:R-DRE-180348] EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] [Complex:R-DRE-180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane]
(output)	[Reaction:R-DRE-212713] Active PLC-gamma1 dissociates from EGFR [Reaction:R-DRE-177934] EGFR autophosphorylation [Reaction:R-DRE-177937] Phosphorylation of EGFR by SRC kinase
(inferredTo)	[Complex:R-HSA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane]

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