Reactome | ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:10602696] arachidonate 12(S)-lipoxygenase activity of ALOX12:Fe2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10638300
displayName	ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6
eventOf	[Pathway:R-DRE-9025106] Biosynthesis of DPAn-6 SPMs - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9025957] ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 - Homo sapiens
input	[SimpleEntity:R-ALL-9025155] DPAn-6 [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6
output	[SimpleEntity:R-ALL-9025960] 14(S)-HDPAn-6 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-9025957
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-9025106] Biosynthesis of DPAn-6 SPMs
(inferredTo)	[Reaction:R-HSA-9025957] ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6

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