Reactome | KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers

Schema > Reaction > Entries

KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers Show undefined attributes

catalystActivity	[CatalystActivity:10637160] histone H3K9 demethylase activity of KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10637162
displayName	KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers
eventOf	[Pathway:R-DRE-9018519] Estrogen-dependent gene expression - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9011949] KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers - Homo sapiens
input	[Complex:R-DRE-9011913] KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers
output	[EntityWithAccessionedSequence:R-DRE-3214396] kdm4b [nucleoplasm] [Complex:R-DRE-9011911] KDM4B-regulated genes:nucleosome:ESR1:ESTG [nucleoplasm]
precedingEvent	[Reaction:R-DRE-9011952] ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-9011949
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-9018519] Estrogen-dependent gene expression
(inferredTo)	[Reaction:R-HSA-9011949] KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers

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