Reactome | SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol

Schema > Reaction > Entries

SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10632613] organic acid:sodium symporter activity of SLC5A12 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10632615
displayName	SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol
eventOf	[Pathway:R-DRE-428643] Organic anion transport by SLC5/17/25 transporters - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-373875] BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region - Danio rerio [Reaction:R-DRE-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - Danio rerio
inferredFrom	[Reaction:R-HSA-8876312] SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol - Homo sapiens
input	[DefinedSet:R-ALL-8876310] LACT, PYR, NCA [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol
output	[DefinedSet:R-ALL-8876304] LACT, PYR, NCA [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
precedingEvent	[Reaction:R-DRE-373875] BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region - Danio rerio [Reaction:R-DRE-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-8876312
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-428643] Organic anion transport by SLC5/17/25 transporters
(precedingEvent)	[Reaction:R-DRE-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT [Reaction:R-DRE-373875] BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region
(inferredTo)	[Reaction:R-HSA-8876312] SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol

Cite Us!