Reactome | PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248

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PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 Show undefined attributes

catalystActivity	[CatalystActivity:10631365] protein tyrosine phosphatase activity of Phosphorylated ERBB2:EGFR heterodimers:PTPN18 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10631367
displayName	PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248
eventOf	[Pathway:R-DRE-8863795] Downregulation of ERBB2 signaling - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2455327] negative regulation of ERBB signaling pathway
inferredFrom	[Reaction:R-HSA-8864125] PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-DRE-8864106] Phosphorylated ERBB2:EGFR heterodimers:PTPN18 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248
output	[Complex:R-DRE-8864118] Phosphorylated ERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers:PTPN18 [plasma membrane] 3 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-8864125
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-8863795] Downregulation of ERBB2 signaling
(inferredTo)	[Reaction:R-HSA-8864125] PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248

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