Reactome | 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-DRE-8854978] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] - Danio rerio [Complex:R-DRE-8854399] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] - Danio rerio
consumedByEvent	[Reaction:R-DRE-8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10616102
displayName	2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane]
hasComponent	[Complex:R-DRE-8854160] 2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] [GenomeEncodedEntity:R-DRE-912321] Ghost homologue of p-Y349,Y350,Y427-SHC1 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-8854980] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] - Homo sapiens
maxDepth	6
memberOf	[DefinedSet:R-DRE-8854900] p-5Y-RET:GDNF:GFRA complexes with and without p-SHC1 [plasma membrane] - Danio rerio
name	2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1
producedByEvent	[BlackBoxEvent:R-DRE-8854981] SHC1 in the RET complex is phosphorylated - Danio rerio
schemaClass	Complex
species	[Species:68323] Danio rerio
stId	R-DRE-8854980
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(hasComponent)	[Complex:R-DRE-8854978] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] [Complex:R-DRE-8854399] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane]
(hasMember)	[DefinedSet:R-DRE-8854900] p-5Y-RET:GDNF:GFRA complexes with and without p-SHC1 [plasma membrane]
(input)	[Reaction:R-DRE-8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1
(output)	[BlackBoxEvent:R-DRE-8854981] SHC1 in the RET complex is phosphorylated
(inferredTo)	[Complex:R-HSA-8854980] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane]