Reactome | Insulin receptor signalling cascade

Schema > Pathway > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10647702
displayName	Insulin receptor signalling cascade
eventOf	[Pathway:R-DRE-74752] Signaling by Insulin receptor - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-109813] GRB2-1 binds SOS1 - Danio rerio [Pathway:R-DRE-74713] IRS activation - Danio rerio [Pathway:R-DRE-112399] IRS-mediated signalling - Danio rerio [Pathway:R-DRE-74749] Signal attenuation - Danio rerio
inferredFrom	[Pathway:R-HSA-74751] Insulin receptor signalling cascade - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	6
name	Insulin receptor signalling cascade
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-74751
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-74752] Signaling by Insulin receptor
(inferredTo)	[Pathway:R-HSA-74751] Insulin receptor signalling cascade

Cite Us!