Reactome | phosphorylation of 2'-Deoxythymidine to dTMP

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phosphorylation of 2'-Deoxythymidine to dTMP Show undefined attributes

catalystActivity	[CatalystActivity:10563243] nucleoside kinase activity of TK1 tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10563245
displayName	phosphorylation of 2'-Deoxythymidine to dTMP
eventOf	[Pathway:R-DRE-73614] Pyrimidine salvage - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-73635] dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] - Danio rerio
inferredFrom	[Reaction:R-HSA-73632] phosphorylation of 2'-Deoxythymidine to dTMP - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-83928] Thy-dRib [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	phosphorylation of 2'-Deoxythymidine to dTMP thymidine + ATP => dTMP + ADP + H(+) thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-109366] TMP [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-73632
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-DRE-73635] dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]
(hasEvent)	[Pathway:R-DRE-73614] Pyrimidine salvage
(inferredTo)	[Reaction:R-HSA-73632] phosphorylation of 2'-Deoxythymidine to dTMP

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