Reactome | TDO tetramer dioxygenates L-Trp to NFK

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TDO tetramer dioxygenates L-Trp to NFK Show undefined attributes

catalystActivity	[CatalystActivity:10561923] L-tryptophan 2,3-dioxygenase activity of TDO2 tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10561925
displayName	TDO tetramer dioxygenates L-Trp to NFK
eventOf	[Pathway:R-DRE-71240] Tryptophan catabolism - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-71188] TDO tetramer dioxygenates L-Trp to NFK - Homo sapiens
input	[SimpleEntity:R-ALL-29500] L-Trp [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	TDO tetramer dioxygenates L-Trp to NFK L-tryptophan + O2 => N-formyl-L-kynurenine tryptophan + O2 => N-formylkynurenine [TDO]
output	[SimpleEntity:R-ALL-33179] NFK [cytosol]
precedingEvent	[Reaction:R-DRE-352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol - Danio rerio [Reaction:R-DRE-8870352] SLC36A4 transports L-Trp from extracellular region to cytosol - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-71188
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-71240] Tryptophan catabolism
(inferredTo)	[Reaction:R-HSA-71188] TDO tetramer dioxygenates L-Trp to NFK

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