Reactome | The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin

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The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin Show undefined attributes

catalystActivity	[CatalystActivity:10560479] DNA-directed DNA polymerase activity of DNA polymerase alpha:primase [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10560481
displayName	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin
eventOf	[Pathway:R-DRE-68952] DNA replication initiation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-113504] Detection of damage during initiation of DNA synthesis in S-phase - Danio rerio [Reaction:R-DRE-69053] RFC binding displaces Pol Alpha - Danio rerio
inferredFrom	[Reaction:R-HSA-68950] The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin - Homo sapiens
input	[SimpleEntity:R-ALL-29604] dATP [nucleoplasm] [SimpleEntity:R-ALL-30185] dCTP [nucleoplasm] [SimpleEntity:R-ALL-29892] dGTP [nucleoplasm] [SimpleEntity:R-ALL-30187] dTTP [nucleoplasm] [Complex:R-DRE-68423] RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin
output	[Complex:R-DRE-68425] RNA primer-DNA primer:origin duplex [nucleoplasm]
precedingEvent	[Reaction:R-DRE-68913] The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-68950
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-68952] DNA replication initiation
(precedingEvent)	[Reaction:R-DRE-113504] Detection of damage during initiation of DNA synthesis in S-phase [Reaction:R-DRE-69053] RFC binding displaces Pol Alpha
(inferredTo)	[Reaction:R-HSA-68950] The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin

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