Reactome | LEAP2 binds bacteria

Schema > Reaction > Entries

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10628513
displayName	LEAP2 binds bacteria
eventOf	[Pathway:R-DRE-6803157] Antimicrobial peptides - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6813626] LEAP2 binds bacteria - Homo sapiens
input	[Complex:R-ALL-8931784] Anionic phospholipids:microbial cell surface [plasma membrane] [DefinedSet:R-DRE-6813660-3] Homologues of LEAP2 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	LEAP2 binds bacteria
output	[Complex:R-DRE-6813633] LEAP2:bacterial phospholipids [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-6813626
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-6803157] Antimicrobial peptides
(inferredTo)	[Reaction:R-HSA-6813626] LEAP2 binds bacteria