Reactome | PCSK9 binds LDLR

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10621255
displayName	PCSK9 binds LDLR
eventOf	[Pathway:R-DRE-8964038] LDL clearance - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6784734] PCSK9 binds LDLR - Homo sapiens
input	[EntityWithAccessionedSequence:R-DRE-171053] ldlra [plasma membrane] [EntityWithAccessionedSequence:R-DRE-6784727] pcsk9 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	PCSK9 binds LDLR
output	[Complex:R-DRE-6784730] PCSK9:LDLR [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-6784734
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-8964038] LDL clearance
(inferredTo)	[Reaction:R-HSA-6784734] PCSK9 binds LDLR