Reactome | JAKs bind OSMR

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10621188
displayName	JAKs bind OSMR
eventOf	[Pathway:R-DRE-6788467] IL-6-type cytokine receptor ligand interactions - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6784204] JAKs bind OSMR - Homo sapiens
input	[CandidateSet:R-DRE-1067656] JAK1, JAK2, (TYK2) [cytosol] [EntityWithAccessionedSequence:R-DRE-448654] lifra [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	JAKs bind OSMR
output	[Complex:R-DRE-6784202] JAKs:OSMR [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-6784204
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-6788467] IL-6-type cytokine receptor ligand interactions
(inferredTo)	[Reaction:R-HSA-6784204] JAKs bind OSMR