Reactome | UV-DDB ubiquitinates XPC

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UV-DDB ubiquitinates XPC Show undefined attributes

catalystActivity	[CatalystActivity:10621025] ubiquitin protein ligase activity of XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10621027
displayName	UV-DDB ubiquitinates XPC
eventOf	[Pathway:R-DRE-5696394] DNA Damage Recognition in GG-NER - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-5696664] PARP1 or PARP2 binds DDB2 at GG-NER site - Danio rerio
inferredFrom	[Reaction:R-HSA-6782943] UV-DDB ubiquitinates XPC - Homo sapiens
input	[DefinedSet:R-DRE-68524] Ub [nucleoplasm] [Complex:R-DRE-5691012] XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	UV-DDB ubiquitinates XPC
output	[Complex:R-DRE-6782948] Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm]
precedingEvent	[Reaction:R-DRE-5691006] XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-6782943
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-5696394] DNA Damage Recognition in GG-NER
(precedingEvent)	[Reaction:R-DRE-5696664] PARP1 or PARP2 binds DDB2 at GG-NER site
(inferredTo)	[Reaction:R-HSA-6782943] UV-DDB ubiquitinates XPC

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