Reactome | ERCC5 and RPA bind TC-NER site

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ERCC5 and RPA bind TC-NER site Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10620984
displayName	ERCC5 and RPA bind TC-NER site
eventOf	[Pathway:R-DRE-6782135] Dual incision in TC-NER - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-6782141] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER - Danio rerio
inferredFrom	[Reaction:R-HSA-6782138] ERCC5 and RPA bind TC-NER site - Homo sapiens
input	[EntityWithAccessionedSequence:R-DRE-67447] ercc5 [nucleoplasm] [Complex:R-DRE-68462] RPA heterotrimer [nucleoplasm] [Complex:R-DRE-6782111] TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	ERCC5 and RPA bind TC-NER site
output	[Complex:R-DRE-6782134] TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm]
precedingEvent	[Reaction:R-DRE-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-6782138
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-6782135] Dual incision in TC-NER
(precedingEvent)	[Reaction:R-DRE-6782141] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
(inferredTo)	[Reaction:R-HSA-6782138] ERCC5 and RPA bind TC-NER site