Reactome | Initial resection of double-strand break ends

Schema > Reaction > Entries

Initial resection of double-strand break ends Show undefined attributes

catalystActivity	[CatalystActivity:10619557] DNA endonuclease activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-BRCA1-C complex [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10619559
displayName	Initial resection of double-strand break ends
eventOf	[Pathway:R-DRE-5693607] Processing of DNA double-strand break ends - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-5685985] EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment - Danio rerio
goBiologicalProcess	[GO_BiologicalProcess:25121] DNA double-strand break processing
inferredFrom	[Reaction:R-HSA-5693608] Initial resection of double-strand break ends - Homo sapiens
input	[Complex:R-DRE-5684107] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-BRCA1-C complex [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Initial resection of double-strand break ends
output	[Complex:R-DRE-5685983] 3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] [SimpleEntity:R-ALL-30555] dNTP [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5693608
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-5693607] Processing of DNA double-strand break ends
(precedingEvent)	[Reaction:R-DRE-5685985] EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
(inferredTo)	[Reaction:R-HSA-5693608] Initial resection of double-strand break ends

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