Reactome | Sensing of DNA Double Strand Breaks

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Sensing of DNA Double Strand Breaks Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10647760
displayName	Sensing of DNA Double Strand Breaks
eventOf	[Pathway:R-DRE-5693606] DNA Double Strand Break Response - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-DRE-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Danio rerio
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-75172] Formation of RAD50:MRE11 complex - Danio rerio [Reaction:R-DRE-5684008] NBN binds KPNA2 - Danio rerio [Reaction:R-DRE-5684006] KPNA2 translocates NBN to the nucleus - Danio rerio [Reaction:R-DRE-75174] Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction - Danio rerio [Reaction:R-DRE-3785768] MRN complex binds DNA double strand breaks - Danio rerio [Reaction:R-DRE-5693612] MRN complex bound to DNA ends recruits ATM - Danio rerio [Reaction:R-DRE-5682044] KAT5 acetylates ATM at DNA DSBs - Danio rerio [Reaction:R-DRE-5693540] MRN activates ATM - Danio rerio
inferredFrom	[Pathway:R-HSA-5693548] Sensing of DNA Double Strand Breaks - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Sensing of DNA Double Strand Breaks
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-5693548
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-5693606] DNA Double Strand Break Response
(precedingEvent)	[Pathway:R-DRE-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
(inferredTo)	[Pathway:R-HSA-5693548] Sensing of DNA Double Strand Breaks