Reactome | DCLRE1C (ARTEMIS) processes DNA DSB ends

Schema > Reaction > Entries

DCLRE1C (ARTEMIS) processes DNA DSB ends Show undefined attributes

catalystActivity	[CatalystActivity:10619461] endonuclease activity of p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:DNA DSB ends [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10619463
displayName	DCLRE1C (ARTEMIS) processes DNA DSB ends
eventOf	[Pathway:R-DRE-5693571] Nonhomologous End-Joining (NHEJ) - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-5693578] TDP1 and TDP2 process unligatable DSB ends - Danio rerio
inferredFrom	[Reaction:R-HSA-5693533] DCLRE1C (ARTEMIS) processes DNA DSB ends - Homo sapiens
input	[Complex:R-DRE-5687161] p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:DNA DSB ends [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	DCLRE1C (ARTEMIS) processes DNA DSB ends
output	[Complex:R-DRE-5693546] p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:Trimmed DNA DSB ends [nucleoplasm]
precedingEvent	[Reaction:R-DRE-5687183] PRKDC phosphorylates DCLRE1C at DNA DSBs - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5693533
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-5693571] Nonhomologous End-Joining (NHEJ)
(precedingEvent)	[Reaction:R-DRE-5693578] TDP1 and TDP2 process unligatable DSB ends
(inferredTo)	[Reaction:R-HSA-5693533] DCLRE1C (ARTEMIS) processes DNA DSB ends

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