Reactome | mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane]

Schema > Complex > Entries

compartment	[Compartment:17938] lysosomal membrane
componentOf	[Complex:R-DRE-5675791] MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10570398
displayName	mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane]
hasComponent	[Complex:R-DRE-5693283] mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] [Complex:R-DRE-165189] RHEB:GTP [lysosomal membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-5693284] mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] - Homo sapiens [Complex:R-HSA-5675700] MTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:RHEB:GTP [lysosomal membrane] - Homo sapiens
maxDepth	8
name	mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP
negativelyRegulates	[NegativeRegulation:10570401] Negative regulation by 'mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane]'
producedByEvent	[Reaction:R-DRE-447074] AMPK phosphorylates Raptor in the mTORC1 complex - Danio rerio [Reaction:R-DRE-5675790] MTORC1 dissociates from ULK complex - Danio rerio
schemaClass	Complex
species	[Species:68323] Danio rerio
stId	R-DRE-5693284
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(regulator)	[NegativeRegulation:10570401] Negative regulation by 'mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane]'
(output)	[Reaction:R-DRE-447074] AMPK phosphorylates Raptor in the mTORC1 complex [Reaction:R-DRE-5675790] MTORC1 dissociates from ULK complex
(inferredTo)	[Complex:R-HSA-5693284] mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] [Complex:R-HSA-5675700] MTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:RHEB:GTP [lysosomal membrane]
(hasComponent)	[Complex:R-DRE-5675791] MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane]

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