Reactome | Long-range resection of DNA DSBs by EXO1 or DNA2

Schema > Reaction > Entries

Long-range resection of DNA DSBs by EXO1 or DNA2 Show undefined attributes

catalystActivity	[CatalystActivity:10617426] DNA nuclease activity of 3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10617428
displayName	Long-range resection of DNA DSBs by EXO1 or DNA2
eventOf	[Pathway:R-DRE-5693607] Processing of DNA double-strand break ends - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-5693542] Association of RPA complexes with ssDNA at resected DNA DSBs - Danio rerio
inferredFrom	[Reaction:R-HSA-5685994] Long-range resection of DNA DSBs by EXO1 or DNA2 - Homo sapiens
input	[Complex:R-DRE-5685989] 3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Long-range resection of DNA DSBs by EXO1 or DNA2
output	[Complex:R-DRE-5684128] 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] [SimpleEntity:R-ALL-30555] dNTP [nucleoplasm]
precedingEvent	[Reaction:R-DRE-5685985] EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5685994
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-5693607] Processing of DNA double-strand break ends
(precedingEvent)	[Reaction:R-DRE-5693542] Association of RPA complexes with ssDNA at resected DNA DSBs
(inferredTo)	[Reaction:R-HSA-5685994] Long-range resection of DNA DSBs by EXO1 or DNA2