Reactome | RNF8 and RNF168 ubiquitinate H2AFX

Schema > Reaction > Entries

RNF8 and RNF168 ubiquitinate H2AFX Show undefined attributes

catalystActivity	[CatalystActivity:10616858] ubiquitin protein ligase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10616860
displayName	RNF8 and RNF168 ubiquitinate H2AFX
eventOf	[Pathway:R-DRE-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-5683077] RNF8 and RNF168 ubiquitinate KDM4A,B - Danio rerio
inferredFrom	[Reaction:R-HSA-5682858] RNF8 and RNF168 ubiquitinate H2AFX - Homo sapiens
input	[Complex:R-DRE-5682859] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] 12 × [DefinedSet:R-DRE-68524] Ub [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	RNF8 and RNF168 ubiquitinate H2AFX
output	[Complex:R-DRE-5682861] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm]
precedingEvent	[Reaction:R-DRE-5682863] RNF168 binds DNA DSBs - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5682858
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
(precedingEvent)	[Reaction:R-DRE-5683077] RNF8 and RNF168 ubiquitinate KDM4A,B
(inferredTo)	[Reaction:R-HSA-5682858] RNF8 and RNF168 ubiquitinate H2AFX