Reactome | FRS-mediated FGFR2 signaling

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FRS-mediated FGFR2 signaling Show undefined attributes

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10650024
displayName	FRS-mediated FGFR2 signaling
eventOf	[Pathway:R-DRE-5654696] Downstream signaling of activated FGFR2 - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-5654399] Activated FGFR2 binds FRS2 - Danio rerio [Reaction:R-DRE-5654603] Activated FGFR2 binds FRS3 - Danio rerio [Reaction:R-DRE-5654397] Activated FGFR2 phosphorylates FRS2 - Danio rerio [Reaction:R-DRE-5654605] Activated FGFR2 phosphorylates FRS3 - Danio rerio [Reaction:R-DRE-5654615] Activated FGFR2:pFRS binds GRB2:SOS1 - Danio rerio [Reaction:R-DRE-5654618] Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Danio rerio [Reaction:R-DRE-5654607] Activated FGFR2 phosphorylates PPTN11 - Danio rerio [Reaction:R-DRE-8941618] Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Danio rerio
inferredFrom	[Pathway:R-HSA-5654700] FRS-mediated FGFR2 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	FRS-mediated FGFR2 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-5654700
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-5654696] Downstream signaling of activated FGFR2
(inferredTo)	[Pathway:R-HSA-5654700] FRS-mediated FGFR2 signaling

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